Five different players rushed for a touchdown and Tyler Shough threw for 349 yards and two touchdowns as No. 22 Louisville cruised to a 49-14 win over visiting Jacksonville State on Saturday.

Maurice Turner, Don Chaney Jr., Keyjuan Brown, Duke Watson and Duane Martin all scored rushing touchdowns for the Cardinals (2-0).

Turner led the Cardinals with 12 carries for 60 yards. Louisville rushed 36 times for 233 yards.

Shough, a seventh-year transfer from Texas Tech, finished 21-of-33 passing after throwing four touchdowns in the first half last week against Austin Peay.

Louisville finished with 610 yards of total offense, while Jacksonville State had 199 of its 290 total yards of offense in the first half. The Cardinals held the Gamecocks to 2-of-12 on third downs and Quincy Riley had an interception — the only turnover of the game.

Shough gave way to backup Harrison Bailey for the final half of the fourth quarter.

Chaney scored on the opening drive with a 10-yard run on a nine-play, 62-yard drive. On the third possession, Keyjuan Brown scampered 22 yards for a 14-0 lead.

Turner made it 21-7 with a 1-yard plunge to cap a nine-play, 70-yard drive early in the second quarter and Duane Martin’s 2-yard run made it 28-7. The Gamecocks had 130 total yards in the second quarter and cut it to 28-14 at the half.

But the Cardinals held them to three-and-out on the first possession of the second half and the offense did the rest. Shough hit Chris Bell on a 48-yard TD pass to make it 35-14 before tight end Mark Redman capped an 11-play, 96-yard drive with a 12-yard TD catch.

On that drive, Cataurus Hicks had a 51-yard catch.

Watson ended the scoring with a 40-yard TD run late in the fourth to make it 49-14.

The Gamecocks (0-2) were led by quarterback Tyler Huff, who ran 18 times for 101 yards and one TD and completed 17 of 27 passes for 160 yards and one TD.