Missouri quarterback Brady Cook left Saturday’s game against Auburn in the first quarter with an ankle injury.

Cook came up limping on the first series for No. 19 Missouri after his leg came out from under him on a non-contact play. He jogged off the field with a trainer.

The third-year starter, who is a St. Louis-area native, was replaced by veteran quarterback Drew Pyne, who previously played at Notre Dame and Arizona State.

ESPN reported in the second quarter that Cook was still being evaluated, with an update expected at the half.

Cook completed 3 of 4 pass attempts for 37 yards before he departed with just under 12 minutes left in the first quarter.

In an interview on Sports Radio 810WHB earlier this week, Cook said he had been “a little dinged up, lower-body wise” but was feeling good and “ready to make some plays this weekend.”

Entering Saturday’s game, Cook had thrown for 1,351 yards with seven touchdowns and an interception in the first six games. He had added four rushing touchdowns.

Prior to Saturday, he appeared in 40 games over five seasons for the Tigers, with 7,824 passing yards, 45 touchdowns and 13 interceptions. He also had 1,110 rushing yards and 19 TDs.

The game was tied 3-3 at halftime.