Missouri quarterback Brady Cook will miss Saturday’s contest against visiting Oklahoma due to ankle and wrist injuries.

Cook’s status was in doubt all week but the school downgraded him to out on Friday’s Southeastern Conference injury report.

The missed contest will end Cook’s streak of 35 consecutive starts. He ranks fourth in school history with 8,053 career passing yards and sits fifth with 45 touchdown passes.

Drew Pyne will start in place of Cook for the No. 24 Tigers (6-2, 2-2 SEC), who are coming off a bye.

Cook has passed for 1,575 yards and seven touchdowns in eight games this season. He has thrown just one interception in 218 attempts. He also has rushed for four touchdowns.

Cook initially injured the ankle during a 21-17 victory over visiting Auburn on Oct. 19. He was hurt in the first quarter, went to a nearby hospital for an MRI exam, returned to the field in the third quarter and rallied Missouri to a victory.

One week later, Cook exited with the wrist injury during the Tigers’ 34-0 loss to Alabama.

Pyne has passed for 248 yards, no touchdowns and three interceptions in 55 attempts this season. He previously played three seasons at Notre Dame (he was the starter in 2022) and one season at Arizona State before transferring to Missouri.